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What are the long term effects of hydroxyurea? These side effects are less common side effects (occurring in about 10-29%) of patients receiving Hydroxyurea: Hair loss (mild thinning) Nausea and vomiting. Diarrhea. Mouth sores. Poor appetite. Nail thickening, nail banding (see skin reactions) Discoloration of the skin or nails (see skin reactions)
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